A Managerial View of Translational Medicine

Translational Medicine principal goal is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. In order to achieve this purpose, translational medicine calls for a synergy between epidemiology, basic research and clinical trials, and is strongly based upon innovation management and research development in medicine. For this reason a managerial view of translational medicine is particularly prolific in terms of insights for researchers and clinicians who place efforts to improve health service

Enabling RAN Slicing Through Carrier Aggregation in mmWave Cellular Networks

The ever increasing number of connected devices and of new and heterogeneous mobile use cases implies that 5G cellular systems will face demanding technical challenges. For example, Ultra-Reliable Low-Latency Communication (URLLC) and enhanced Mobile Broadband (eMBB) scenarios present orthogonal Quality of Service (QoS) requirements that 5G aims to satisfy with a unified Radio Access Network (RAN) design. Network slicing and mmWave communications have been identified as possible enablers for 5G. They provide, respectively, the necessary scalability and flexibility to adapt the network to each specific use case environment, and low latency and multi-gigabit-per-second wireless links, which tap into a vast, currently unused portion of the spectrum. The optimization and integration of these technologies is still an open research challenge, which requires innovations at different layers of the protocol stack. This paper proposes to combine them in a RAN slicing framework for mmWaves, based on carrier aggregation. Notably, we introduce MilliSlice, a cross-carrier scheduling policy that exploits the diversity of the carriers and maximizes their utilization, thus simultaneously guaranteeing high throughput for the eMBB slices and low latency and high reliability for the URLLC flows.Comment: 8 pages, 8 figures. Proc. of the 18th Mediterranean Communication and Computer Networking Conference (MedComNet 2020), Arona, Italy, 202

From knowledge co-creation to value co-creation and beyond: challenging global emergency in smart service systems.

The study seeks to investigate the impact of pandemic on teaching and learning processes involved in Higher Education (HE) by analysing the way in which knowledge exchange and value co-creation are reframed through ICTs and technology. The adoption of the interpretative lens of Service Science permits to reread HE as a smart service system. The empirical research, based on content analysis as an inquiry, analyses: 1) the transformations introduced in technology adoption, information sharing, knowledge and value co-creation to comply with the disruption “imposed” by the the sanitary emergency; 2) the way in which this transformation can introduce novelties in Higher education system. The results identify the different drivers for value and knowledge co-creation that can be implemented in technology-enhanced teaching and learning and the different novelties that can be generated from the emergence of innovation

The Role of Emergence in Service Systems

It has been recognized that a service systems perspective, informed by service-dominant logic, provides a dynamic approach for studying value co-creation. According to this view, value is the increase in the viability of the system in which actors co-create value. A construct from systems theory – emergence – can be of particular interest in contributing to and detracting from systems viability. Emergence is related to the nonlinear interactions characterizing systems’ elements that can give rise to novel and unpredictable properties not contained in the elements. This paper relates emergence to service systems based on the service-dominant logic and systems theory literature. Such issues can be useful for service science scholars to identify new research avenues for service systems

An Introduction to the Viable Systems Approach and its Contribution to Marketing

Organizations are increasingly challenged by dynamism and turbulence that determine conditions of complexity in decision making. The aim of this paper is to highlight the need for a general frame of reference for management and marketing and to justify why adopting a systems approach is adequate at both theoretical and practical level. Specifically, the purpose of this paper is to explain why a systems approach is needed to understand business and market dynamics, and why the VSA may represent a good integrator of management and marketing theories and practices. The paper begins with a brief review of systems theories that have been proposed in the general context of management and marketing. It proceeds by illustrating the fundamental principles and concepts of the VSA and its contribution to marketing. The paper closes by discussing future research avenues and suggesting implications for researchers and practitioners

Reflections on Service Systems Boundaries: A Viable Systems Perspective. The case of the London Borough of Sutton

The aim of this paper is to propose a systems interpretation of the concept of complexity and its implications for a theoretical discussion of the concept of boundary in complex service systems. The proposal highlights the interpretative contribution of a dual perspective of observation that distinguishes between a structure-based view and a systems-based view. When dealing with complexity, the phenomenon under investigation cannot be addressed through management approaches that aim to measure and control it in a vain attempt to find the best solution. Due to the inner nature of complexity, a more rewarding approach to a full understanding of problematic situations should place consolidated management models within a more general interpretation framework that suggests preliminary insights about the real nature of the investigated phenomenon. First, this paper outlines the theoretical background of the literature on service, service systems and complex service systems, providing evidence of the contribution of recent service research advances such as service science and service-dominant logic. Next, the paper focuses on the basic principles of systems thinking to introduce the Viable Systems Approach (vSa) as a general framework of reference for both the investigation and the governance of social organisations. The vSa conceptual framework is adopted for proposing some reflections from a systems perspective in the investigation of the case of the London Borough of Sutton (LBS). The focus is on interpreting the paradoxical situation of an increased fear of crime among LBS residents despite the evidence of reduction in the crime rate. Although the incidence has fallen for most types of crimes, a recent poll confirmed that crime is still rated as the most important issue for residents. Therefore, improving safety and reducing crime remain the top priorities for the Safer Sutton Partnership Service. In short, this study proposes to consider ‘‘reducing the fear of crime in a community’’ as a complex service system

The determinants of translational medicine success - A managerial contribution

Scope of Translational Medicine is to speed the development of new compounds of medical protocols and/or treatments to improve patient’s quality of life. Translational medicine represents the synergy between epidemiology, basic research and clinical trials, and is based upon Innovation Management and Research Development in medicine. Being the speed and progression up to the patient a key issue of Translational Medicine, the innovation process ought to be pursued according to rigorous protocols embedded on a research development path capable of decreasing the lead time at the most. Translational Medicine represents a goal to be pursued by all involved actors, from academic researchers to clinicians, patients and others than can be seen as a network of co-creating actors engaged for the ultimate patient benefit. To underpin Translational Medicine advantages and determinants, the paper approaches the issue by adopting a systems thinking perspective, capable of highlighting the key issues to be considered

Mixed Graph of Terms: Beyond the bags of words representation of a text

The main purpose of text mining techniques is to identify common patterns through the observation of vectors of features and then to use such patterns to make predictions. Vectors of features are usually made up of weighted words, as well as those used in the text retrieval field, which are obtained thanks to the assumption that considers a document as a "bag of words". However, in this paper we demonstrate that, to obtain more accuracy in the analysis and revelation of common patterns, we could employ (observe) more complex features than simple weighted words. The proposed vector of features considers a hierarchical structure, named a mixed Graph of Terms, composed of a directed and an undirected sub-graph of words, that can be automatically constructed from a small set of documents through the probabilistic Topic Model. The graph has demonstrated its efficiency in a classic "ad-hoc" text retrieval problem. Here we consider expanding the initial query with this new structured vector of features